Assessment Of Acute Phase Protein - 1216 Words

DEPARTMENT OF BIOCHEMISTRY FACULTY OF MEDICINE UNIVERSITY OF KHARTOUM Assessment of acute phase protein (plasminogen activating inhibitor) levels and in type 2 Sudanese diabetic patients A research proposal for master degree of medical biochemistry By Khalid M.Elhassan Osman Abdelsamad Supervisor Dr. Khalid Hussein Introduction and literature review: Diabetes mellitus is a metabolic disorder of multiple etiologies. It is characterized by chronic hyperglycemia together with disturbances of carbohydrate, fat and protein metabolism resulting from defects of insulin secretion, insulin action or both.(1) Type 2 diabetes (formerly called non-insulin-dependent or adult onset diabetes) is caused by the body’s ineffective use of insulin. It often results from excess body weight and physical inactivity. The expected number of diabetic patients 438 million by 2030, an increase of 54% compared to predicted figures for 2010(2). Macro vascular diseases such as coronary artery disease are one of complications of both type 1 and type 2 diabetes mellitus. The prevalence of diabetes is increasing, now diabetes also affects adolescents and younger adults, thus promoting the earlier development of long term cardiovascular complications. Diabetes itself accounts for 75 – 90% of the excess coronary art ery disease (CAD) risk and enhances the effects of other cardiovascular risk factors. Death from stroke and myocardial infarction (MI) are the leadingShow MoreRelatedLab Report On Biochemical Assessment880 Words   |  4 Pages PUID _0026259309_______________________ LAB: Monday Thursday (circle one) Week 2 Lab Assignment: Biochemical Assessment Paper Copy Due in Lab Week of September 12 Submit Electronic Copy on Safe Assign in Blackboard REFERENCES TO USE: Nelms Textbook - Appendix E and assigned readings Read the Case Study posted on Blackboard. Questions #1 to #9 pertain to the Case Study. 1. Define the following terms: - pancytopenia: deficiency of red cells, white cells, and platelets in the bloodRead MoreMalnutrition Increases Morbidity and Mortality Essay1183 Words   |  5 Pagesbetween intake and requirement that changes metabolism, loss of body mass, and impaired function.1 Malnutrition is a common problem among patients with severe or chronic diseases. The main cause of malnutrition in developed countries is disease. Either acute or chronic disorder can aggravate malnutrition in many ways such as change in metabolism due to infection or inflammation, response to trauma, absorption, or appetite. Other than pathological causes for malnutrition, socioeconomic factors such asRead MoreThe Health Of The Livestock Production Of Poultry Carrying An Infectious Disease1497 Words   |  6 PagesThe Acute phase proteins are produced as the develop of a response caused after a variety of conditions stimulated by inflammatory cells producing chemical substances that activate specific organs to produce these proteins to reconstitute homeostasis and thus restore the injured tissue. Even though the Acute Phase Response generated is not specific for each determined disease, the measurement of these proteins in an animal may indicate the occurrence of an unhealthy condition, and a further diagnosisRead MoreThe Effects Of Blood Analysis On Veterinary Practice1488 Words   |  6 Pagespresence of acute or chronic inflammation or infection or of immunoproliferative disorders. Alongside of traditional hematologic analyses, considerable progress has been made in the understanding of acute phase response in veterinary medicine over recent years, to the point that measurement of acute phase proteins has proved as a powerful tool to enhance clinical evaluation in domestic animals for diagnostic, monitoring and prognostic purposes (Eckersall and Bell, 2010). The acute phase response (APR)Read MoreThe Effects Of Blood Analysis On Veterinary Practice1488 Words   |  6 Pagespresence of acute or chronic inflammation or infection or of immunoproliferative disorders. Alongside of traditional hematologic analyses, considerable progress has been made in the understanding of acute phase response in veterinary medicine over recent years, to the point that measurement of acute phase proteins has proved as a powerful tool to enhance clinical evaluation in domestic animals for diagnostic, monitoring and prognostic purposes (Eckersall and Bell, 2010). The acute phase response (APR)Read MoreProteomics Analysis On Prostate Cancer1195 Words   |  5 PagesComparative proteomics analysis of urine reveals down-regulation of Acute Phase Response Signaling and LXR/RXR activation pathways in prostate cancer Abstract: Detecting prostate cancer (PCa) using non-invasive diagnostic markers still remains a challenge. The aim of this study was the identification of urine proteins sufficiently sensitive and specific to detect PCa in the early stages. Comparative proteomics profiling of urine from patients with PCa, benign prostate hyperplasia, bladder cancerRead MoreAcute Respiratory Distress Syndrome ( Ards )1122 Words   |  5 Pages According to the American Lung Association, â€Å"Acute respiratory distress syndrome (ARDS) is a rapidly progressive disease occurring in critically ill patients.† ARDS is an extreme manifestation of a lung injury that can be associated with an acute medical problem. This occurs as a result of direct or indirect trauma to the lungs. With nearly 200,000 cases in the United States each year, ARDS is not extremely common (â€Å"Acute Respiratory Distress Syndrome†). Most people who acquire this disease areRead MoreThe Effects Of Injury Assessment On Athletes Participating961 Words   |  4 Pagesor a twist to the knee, or result from overuse of a muscle, tendon, or bone (1). This information will be helpful when assessing an injury. The three steps of injury assessment are, determine the type and extent of the injury, locate signs and symptoms, and finally compare bilaterally to notice any deformities (2). Our injury assessment is aided by the popular acronym H.O.P.S. Which stands for history, observation, palpation, and special tests. History is crucial for diagnosing an injury and wouldRead MoreRheumatoid Arthritis : The Commonest Form Of Inflammatory Arthritis985 Words   |  4 Pagesphysical examination, acute phase reactants, patient and physician global assessment of disease activity and patient assessment of pain and fatigue (Salomon-Escoto et al. 2011). To standardise these measures, the American College of Rheumatology (ACR), and the European League Against Rheumatism (EULAR) have proposed ‘core data set of ou tcome measures’ that includes: swollen and tender joint counts, patient assessment of pain, patient global assessment, physician global assessment, measurement of functionalRead MoreHepatitis C Virus ( Hcv )1326 Words   |  6 Pagesthe most widely distributed genotypes being types 1, the most common, and type 2. Acute Hepatitis C virus is a short-term infection that occurs within the first 6 months of being exposed to the Hepatitis C virus. Mild symptoms such as fatigue and vomiting within the first six months after exposure may be present, but in many cases, the disease causes no symptoms at all. This extremely problematic because if acute hepatitis C is actually diagnosed, treatment would reduce the risk of a chronic infection